| Name | CR | Type | Environment |
| Earthhallowed Guardian | 10 | construct (magical) | any wellspring (Genrovis) |
| Elebrian | | humanoid (elebrian) | any (Eox)
|
| Electrovore | 2 | magical beast | any |
| Electrovore Colony Troop | 9 | magical beast (troop) | any |
| Elemental, Elder Elemental | 11 | outsider (elemental, extraplanar) | any |
| Elemental, Greater Elemental | 9 | outsider (elemental, extraplanar) | any |
| Elemental, Huge Elemental | 7 | outsider (elemental, extraplanar) | any |
| Elemental, Large Elemental | 5 | outsider (elemental, extraplanar) | any |
| Elemental, Medium Elemental | 3 | outsider (elemental, extraplanar) | any |
| Elemental, Small Elemental | 1 | outsider (elemental, extraplanar) | any |
| Elemental, Tiny Elemental | 1/3 | outsider (elemental, extraplanar) | any |
| Ellicoth | 9 | magical beast | any plains or deserts (Eox) |
| Elmeshra | 7 | animal (aquatic) | temperate aquatic and marsh (Triaxus) |
| Embri | 3 | aberration | any (Embroi) |
| Embri, Embri Speaker | 10 | aberration | any (Embroi) |
| Emergency Workers, Elite Rescuer | 10 | humanoid (vlaka) | — |
| Emergency Workers, Enercopter Pilot | 9 | humanoid (worlanisi) | — |
| Emergency Workers, Hazard Professional | 6 | humanoid (ryphorian) | — |
| Emergency Workers, Hazard Response Crew | 3 | monstrous humanoid | — |
| Emotivore | 9 | undead (shapechanger) | any |
| Emotivore, Emotivore Mastermind | 17 | undead (shapechanger) | any |
| Endiffian | 3 | humanoid (endiffian, shapechanger) | any |
| Endling, Koruvi Endling | 3 | undead (incorporeal) | any (Calen 5) |
| Entropy Slug | 4 | magical beast | underground or urban (Great Shadar) |
| Entu Colony | 1/2 | ooze | any |
| Entu Colony, Nelentu | 7 | animal (entu symbiote) | any forest or urban |
| Eohi | 6 | animal | any forests (Nejeor IV) |
| Epokasite, Fixer | 3 | fey | any land |
| Epokasite, Runner | 8 | fey | any land |
| Equinoxian, Equinoxian Apastra | 15 | outsider (native) | any |
| Equinoxian, Equinoxian Periastra | 9 | outsider (native) | any |
| Espraksa | 1/2 | humanoid (espraksa) | any (Neeroon) |
| Espraksa, Espraksa Performer | 4 | humanoid (espraksa) | any (Neeroon) |
| Exhaust Ooze | 18 | ooze (air) | any urban |
| Exsiccate | 12 | undead | any |
| Eyeswide Headscanner | 4 | humanoid (lashunta) | any (Absalom Station) |